Should the PANSS Be Rescaled?
Identifieur interne : 000A39 ( Main/Exploration ); précédent : 000A38; suivant : 000A40Should the PANSS Be Rescaled?
Auteurs : Michael Obermeier [Allemagne] ; Andreas Mayr [Allemagne] ; Rebecca Schennach-Wolff [Allemagne] ; Florian Seemüller [Allemagne] ; Hans-Jürgen Möller [Allemagne] ; Michael Riedel [Allemagne]Source :
- Schizophrenia Bulletin [ 0586-7614 ] ; 2009.
Abstract
The design of the Positive and Negative Syndrome Scale (PANSS) with item levels ranging from 1 to 7 leads to the trivial result that the 30-item scale’s zero level (no symptoms) is 30. This causes serious problems when ratios are calculated which always implicitly depend on a natural zero point (equals 0). Recent publications concerning efficacy of antipsychotics correctly suggest a subtraction of 30 points to every PANSS before calculating percent change (PC). Nevertheless, the traditional approach using uncorrected scores is still in common practice. This analysis aims to clarify which approach is the most appropriate from a statistical perspective.For analysis, data from a naturalistic study on 400 patients with a schizophrenic spectrum disorder and simulated data sets were used. While calculations concerning absolute score values and their differences are not affected, considerable problems arise in calculations of PC and related response criteria. Even significance levels of estimated treatment effects change, depending on the structure of the data (eg, baseline symptom severity). Using a PANSS version with items ranging from 0 to 6 would avoid such often neglected pitfalls.
Url:
DOI: 10.1093/schbul/sbp124
PubMed: 19889950
PubMed Central: 2879676
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000631
- to stream Pmc, to step Curation: 000631
- to stream Pmc, to step Checkpoint: 000391
- to stream Ncbi, to step Merge: 000346
- to stream Ncbi, to step Curation: 000346
- to stream Ncbi, to step Checkpoint: 000346
- to stream Main, to step Merge: 000A48
- to stream Main, to step Curation: 000A39
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Should the PANSS Be Rescaled?</title><author><name sortKey="Obermeier, Michael" sort="Obermeier, Michael" uniqKey="Obermeier M" first="Michael" last="Obermeier">Michael Obermeier</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Mayr, Andreas" sort="Mayr, Andreas" uniqKey="Mayr A" first="Andreas" last="Mayr">Andreas Mayr</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Schennach Wolff, Rebecca" sort="Schennach Wolff, Rebecca" uniqKey="Schennach Wolff R" first="Rebecca" last="Schennach-Wolff">Rebecca Schennach-Wolff</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Seemuller, Florian" sort="Seemuller, Florian" uniqKey="Seemuller F" first="Florian" last="Seemüller">Florian Seemüller</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Moller, Hans Jurgen" sort="Moller, Hans Jurgen" uniqKey="Moller H" first="Hans-Jürgen" last="Möller">Hans-Jürgen Möller</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Riedel, Michael" sort="Riedel, Michael" uniqKey="Riedel M" first="Michael" last="Riedel">Michael Riedel</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19889950</idno><idno type="pmc">2879676</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879676</idno><idno type="RBID">PMC:2879676</idno><idno type="doi">10.1093/schbul/sbp124</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000631</idno><idno type="wicri:Area/Pmc/Curation">000631</idno><idno type="wicri:Area/Pmc/Checkpoint">000391</idno><idno type="wicri:Area/Ncbi/Merge">000346</idno><idno type="wicri:Area/Ncbi/Curation">000346</idno><idno type="wicri:Area/Ncbi/Checkpoint">000346</idno><idno type="wicri:doubleKey">0586-7614:2009:Obermeier M:should:the:panss</idno><idno type="wicri:Area/Main/Merge">000A48</idno><idno type="wicri:Area/Main/Curation">000A39</idno><idno type="wicri:Area/Main/Exploration">000A39</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Should the PANSS Be Rescaled?</title><author><name sortKey="Obermeier, Michael" sort="Obermeier, Michael" uniqKey="Obermeier M" first="Michael" last="Obermeier">Michael Obermeier</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Mayr, Andreas" sort="Mayr, Andreas" uniqKey="Mayr A" first="Andreas" last="Mayr">Andreas Mayr</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Schennach Wolff, Rebecca" sort="Schennach Wolff, Rebecca" uniqKey="Schennach Wolff R" first="Rebecca" last="Schennach-Wolff">Rebecca Schennach-Wolff</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Seemuller, Florian" sort="Seemuller, Florian" uniqKey="Seemuller F" first="Florian" last="Seemüller">Florian Seemüller</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Moller, Hans Jurgen" sort="Moller, Hans Jurgen" uniqKey="Moller H" first="Hans-Jürgen" last="Möller">Hans-Jürgen Möller</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Riedel, Michael" sort="Riedel, Michael" uniqKey="Riedel M" first="Michael" last="Riedel">Michael Riedel</name><affiliation wicri:level="3"><nlm:aff id="aff1">Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Nussbaumstrasse 7, 80336 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author></analytic><series><title level="j">Schizophrenia Bulletin</title><idno type="ISSN">0586-7614</idno><idno type="e-ISSN">1745-1701</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The design of the Positive and Negative Syndrome Scale (PANSS) with item levels ranging from 1 to 7 leads to the trivial result that the 30-item scale’s zero level (no symptoms) is 30. This causes serious problems when ratios are calculated which always implicitly depend on a natural zero point (equals 0). Recent publications concerning efficacy of antipsychotics correctly suggest a subtraction of 30 points to every PANSS before calculating percent change (PC). Nevertheless, the traditional approach using uncorrected scores is still in common practice. This analysis aims to clarify which approach is the most appropriate from a statistical perspective.For analysis, data from a naturalistic study on 400 patients with a schizophrenic spectrum disorder and simulated data sets were used. While calculations concerning absolute score values and their differences are not affected, considerable problems arise in calculations of PC and related response criteria. Even significance levels of estimated treatment effects change, depending on the structure of the data (eg, baseline symptom severity). Using a PANSS version with items ranging from 0 to 6 would avoid such often neglected pitfalls.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Obermeier, Michael" sort="Obermeier, Michael" uniqKey="Obermeier M" first="Michael" last="Obermeier">Michael Obermeier</name></region><name sortKey="Mayr, Andreas" sort="Mayr, Andreas" uniqKey="Mayr A" first="Andreas" last="Mayr">Andreas Mayr</name><name sortKey="Moller, Hans Jurgen" sort="Moller, Hans Jurgen" uniqKey="Moller H" first="Hans-Jürgen" last="Möller">Hans-Jürgen Möller</name><name sortKey="Riedel, Michael" sort="Riedel, Michael" uniqKey="Riedel M" first="Michael" last="Riedel">Michael Riedel</name><name sortKey="Schennach Wolff, Rebecca" sort="Schennach Wolff, Rebecca" uniqKey="Schennach Wolff R" first="Rebecca" last="Schennach-Wolff">Rebecca Schennach-Wolff</name><name sortKey="Seemuller, Florian" sort="Seemuller, Florian" uniqKey="Seemuller F" first="Florian" last="Seemüller">Florian Seemüller</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/explor/MozartV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A39 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A39 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Musique
|area= MozartV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:2879676
|texte= Should the PANSS Be Rescaled?
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:19889950" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MozartV1
| This area was generated with Dilib version V0.6.20. |  |